Isoprostanes and asthma
نویسندگان
چکیده
منابع مشابه
Isoprostanes.
The isoprostanes (IsoPs) are a unique series of prostaglandin-like compounds formed in vivo via a nonenzymatic mechanism involving the free radical-initiated peroxidation of arachidonic acid. This article summarizes our current knowledge of these compounds. Herein, a historical account of their discovery and the mechanism of their formation are described. A specific class of IsoPs, the F2-IsoPs...
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Endothelial Dysfunction, Isoprostanes, and Copper Deficiency To the Editor: Following the tradition of using animal experiments to clarify and illustrate human pathology, Lavi et al1 sought similarities between people with ischemic heart disease and animals fed cholesterol. They detected a decreased effect of acetylcholine on coronary arteries in 8 of 20 angiogram patients with minimal coronary...
متن کاملCardiovascular pharmacology and physiology of the isoprostanes.
F(2)-isoprostanes are a complex family of compounds produced from arachidonic acid via a free radical-catalyzed mechanism. Their quantification as a pathophysiological biomarker provides a unique opportunity to investigate lipid peroxidation in vascular diseases. Their measurement also provides an interesting biomarker for the rational dose selection of antioxidants in vascular diseases where o...
متن کاملLipid peroxidation, isoprostanes and vascular damage.
Increased lipid peroxidation has been identified as a key mechanism for the development of atherosclerosis and inflammatory vascular damage. Determination of plasma concentration and urinary excretion of some F(2)-isoprostanes (by immunometric assays or by mass-spectrometry), has been demonstrated to be a reliable approach to the assessment of lipid peroxidation, and therefore of oxidative stre...
متن کامل-Isoprostanes in Human Atherosclerotic Lesions
F 2 -Isoprostanes are prostaglandin (PG) isomers formed in situ in cell membranes by peroxidation of arachidonic acid. 8-epi PGF 2 a and IPF 2 a -I are F 2 -isoprostanes produced in humans which circulate in plasma and are excreted in urine. Measurement of F 2 -isoprostanes may offer a sensitive, specific, and noninvasive method for measuring oxidant stress in clinical settings where reactive o...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2011
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2011.04.016